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Anti-epha2 Antibody (MOM-18552)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human epha2 Antibody MOM-18552 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Mouse Antibody is specific to Human EPHA2, expressed in Chinese Hamster Ovary cells(CHO)
  • Target
  • EPHA2
  • Type
  • IgG
  • Immunogen
  • Recombinant mouse EphA2 extracellular domain
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in Neut, FuncS, ELISA, FC, WB and most other immunological methods.
  • Specificity
  • Tested positive against native antigen.
  • Purity
  • >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Induces apoptosis in a p53/TP53-independent, caspase-8-dependent manner.
  • Function
  • ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transmembrane receptor protein tyrosine kinase activity;
  • Synonyms
  • EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; ECK; CTPA; ARCC2; CTPP1;

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