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Recombinant Mouse Antibody is specific to Human KIR3DL1, expressed in Chinese Hamster Ovary cells(CHO)
Recombinant full length Human KIR3DL1.
Suitable for use in Neut, ICC and most other immunological methods.
Tested positive against native antigen.
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
KIR3DL1 (NKB1, CD158e1) is expressed on a subset of natural killer cells and T cells. NKB1 is a 70 kD member of the immunoglobulin superfamily that is expressed at varying levels among individuals. NKB1 is a type I membrane protein containing two immunoglobulin C2 type domains. The interaction of NKB1 with specific HLA B antigens on a target cell (the HLA Bw4 allele, for example) inhibits cytotoxicity and prevents target cell lysis and death. The interactions between KIR and MHC class I are thought to be important in NK and T cell regulation following antigen stimulation. The absence of ligands for KIRs may lower the threshold for activation through activating receptors and increase inflammation and susceptibility to autoimmune disease.
HLA-B specific inhibitory MHC class I receptor activity; receptor activity;