Anti-notch1 Antibody (MOM-18596)
|Recombinant Anti-Human notch1 Antibody
- Product Overview
- Recombinant Mouse Antibody is against Human NOTCH1, expressed in Chinese Hamster Ovary cells(CHO)
- The details of the immunogen for this antibody are not available.
- Suitable for use in Neut, ELISA, WB and most other immunological methods.
- Specific Activity
- Tested positive against native antigen.
- >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
- Antigen Description
- Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function.
- calcium ion binding; chromatin DNA binding; core promoter binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
- NOTCH1; notch 1; Notch (Drosophila) homolog 1 (translocation associated) , Notch homolog 1, translocation associated (Drosophila) , TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1; hN1; TAN1;
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