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Anti-tnfrsf10a Antibody (MOM-18512)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human tnfrsf10a Antibody MOM-18512 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Mouse Antibody is against Human TNFRSF10A, expressed in Chinese Hamster Ovary cells(CHO)
  • Target
  • TNFRSF10A
  • Type
  • IgG
  • Immunogen
  • Fusion protein (Human). Fusion protein containing the extracellular part of DR4 and the constant part of the heavy chain of the human IgG1.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in Neut, FuncS, IF, IHC and most other immunological methods.
  • Specificity
  • Tested positive against native antigen.
  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Storage
  • At -20°C for one year.

BACKGROUND

  • Antigen Description
  • Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
  • Function
  • TRAIL binding; death receptor activity; protein binding; receptor activity; transcription factor binding;
  • Synonyms
  • TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2; APO2; TRAILR1; TRAILR-1; MGC9365

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