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Recombinant Mouse Antibody scFv Fragment specifically binds to Human TSHR, expressed in E. coli
Fusion protein, corresponding to amino acids 402-415 of Human TSH receptor.
Suitable for use in ELISA, WB, Neut and most other immunological methods.
Tested positive against native antigen.
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
The TSH receptor, a G protein coupled seven transmembrane receptor, is present on the basal surface of thyroid follicular cells. It is involved in regulating thyrocyte cell growth and function by mediating thyroid stimulating hormone (TSH) action. The TSH receptor is also the target autoantigen in autoimmune thyroid diseases. Autoantibodies to the TSH receptor that stimulate cAMP production in thyrocyte cells, called thyroid stimulating antibodies, are responsible for the hyperthyroidism of Graves" Disease. Another class of autoantibodies that block the binding of TSH to the TSH receptor, thyroid blocking antibodies, may mediate the hypothyroidism associated with Hashimoto's thyroiditis, primary myxoedema, and neonatal hypothyroidism. Studies indicate that these autoantibodies interact primarily with the extracellular region of the TSH receptor. TSH receptor expression has been reported in adipose, adrenal, brain, eye, heart, kidney, skin, thymus, and thyroid. ESTs have been isolated from brain, placenta, and thyroid libraries.
protein binding; receptor activity; signal transducer activity; thyroid-stimulating hormone receptor activity; thyroid-stimulating hormone receptor activity;