Anti-Rabies Virus Glycoprotein Antibody Fab

Cat

MOM-18101-F(P)

Product Overview

Recombinant Human Antibody Fab Fragment specifically binds to Rabies virus, expressed in E. coli

Target

Rabies virus

Type

Fab Fragment based on Human IgG1 - lambda

Species Reactivity

Rabies virus

Expression Host

E. coli

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Predicted N terminal

H chain: QVQLVQS; L Chain: QSALTQP

Purity

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage

Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Introduction

Recombinant monoclonal antibody (from direct b cell isolation antibody) for the prophylaxis of rabies.

Antigen Description

Rabies virus (Neurotropic lyssavirus) is a member of the Rhabdoviridae family. Rabies is a single stranded, neurotropic, negative sense RNA virus which encodes 5 proteins: a glycoprotein, a nucleoprotein, and three others. The mature virus has a bullet shape, a protein coat, and a lipid envelope. The outer surface of the virus is covered with thumblike glycoprotein projections 5-10 nm long and 3 nm in diameter. The virus averages approximately 780 nm in length. Virus infectivity is destroyed by lipid solvents. Rabies virus is a very successful virus, with a very wide range of hosts. It causes an acute, central nervous system infection, characterized by CNS irritation, followed by paralysis and death. Approximately 50,000 human deaths each year are caused by rabies.

Keywords

rabies virus; rabies virus glycoprotein

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