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- Anti-TACSTD2-PEG6-MMAD ADC-1
Anti-TACSTD2-PEG6-MMAD ADC-1 (CAT#: ADC-W-292)
This ADC product is comprised of an anti-TACSTD2 monoclonal antibody (clone 7E6) conjugated via a PEG6 linker to MMAD. The MMAD is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAD binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- 7E6
- Name
- TACSTD2
- Alternative Names
- TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic ca
- Target Entrez Gene ID
- 4070
- Target UniProt ID
- P09758
- Overview
- This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.
- Overview
- Humanized Anti-TACSTD2 antibody, clone # 7E6
- Clone #
- 7E6
- Species Reactivity
- Human
- Name
- PEG6 ((Propylene Glycol)-6-propionyl)
- Description
- Polyethylene glycol (PEG) is a polyether compound with many applications from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
- Name
- MMAD (monomethyl auristatin D)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
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Other Products
Same Target
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-290 | Anti-TACSTD2-AcLys-VC-PABC-MMAD ADC-1 | AcLys-VC- PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl) | MMAD (monomethyl auristatin D) |
| ADC-W-563 | Anti-TACSTD2-VC-PABC-Aur0101 ADC-2 | VC-PABC (valine-citrulline-p-aminobenzylcarbamate) | Aur0101 |
| ADC-W-538 | Anti-TACSTD2-PEG6-MMAD ADC-2 | Amino-PEG6-based linker | MMAD (monomethyl auristatin D) |
| ADC-W-293 | Anti-TACSTD2-AcLys-VC-PABC-0101 ADC-1 | AcLys-VC- PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl) | 2-methylalanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide) |
| ADC-W-570 | Anti-TACSTD2-Mc-VC-MMAD ADC-2 | Mc-VC (maleimidocaproyl-valine-alanine) | MMAD (monomethyl auristatin D) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-634 | Anti-ERBB2 (trastuzumab)-AcLys-β-Ala-MMAD ADC | AcLys-β-ala | MMAD (monomethyl auristatin D) |
| ADC-W-632 | Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAD ADC | Aminocaproyl | MMAD (monomethyl auristatin D) |
| ADC-W-538 | Anti-TACSTD2-PEG6-MMAD ADC-2 | Amino-PEG6-based linker | MMAD (monomethyl auristatin D) |
| ADC-W-631 | Anti-ERBB2 (trastuzumab)-AcLys-VC-PABC-MMAD ADC | AcLys-VC-PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl) | MMAD (monomethyl auristatin D) |
| ADC-W-570 | Anti-TACSTD2-Mc-VC-MMAD ADC-2 | Mc-VC (maleimidocaproyl-valine-alanine) | MMAD (monomethyl auristatin D) |
For Research Use Only. NOT FOR CLINICAL USE.
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