anti-HIgG(Fc)Fab-C-PNU ADC (ADC-AA-014)

This ADC product is comprised of a Fab fragment of an anti-human IgG Fc specific polyclonal antibody conjugated via a cleavable linker to PNU-159682. The antibody portion is a Fab fragment of a secondary antibody and the drug portion, PNU-159682, is a cytotoxic small molecule which binds to DNA, causes DNA damage. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.

 ADC Target

  • Name
  • IgG Fc
  • Overview
  • The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.

 ADC Antibody

  • Overview
  • Fab fragment of anti-human IgG Fc specific polyclonal antibody
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • Cleavable linkers
  • Description
  • Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.

 ADC payload drug

  • Name
  • PNU-159682
  • Description
  • PNU-159682 is a major bioactive metabolite of Nemorubicin in human liver microsomes;> 3,000-fold cytotoxic than its parent compound (MMDX and doxorubicin).

For Research Use Only. NOT FOR CLINICAL USE.


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