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Anti-TNFRSF10B-Mc-MMAF ADC-1 (CAT#: ADC-W-387)

This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (hTRA-8) conjugated via a MC linker to a MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • TNFRSF10B
  • Alternative Names
  • TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cyto
  • Target Entrez Gene ID
  • 8795
  • Overview
  • The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
  • Overview
  • Anti-TNFRSF10B Antibody, hTRA-8
  • Generic name
  • hTRA-8
  • Species Reactivity
  • Human
  • Name
  • Mc (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Name
  • MMAF (Monomethyl auristatin F)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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ADC-W-517 Anti-TM4SF1-Mc-LP2 ADC-1 Mc (maleimidocaproyl) LP2 (chemical name mc-3377)
ADC-W-2606 Anti-ITGB3 (Tadocizumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-493 Anti-CD19-Mc-MMAF ADC-3 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-2622 Anti-NCAM1 (Lorvotuzumab )-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-491 Anti-TNFRSF17-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
CAT# Product Name Linker Payload
ADC-AA-020 anti-MIgG(Fc)-C-MMAF ADC Cleavable linkers MMAF (Monomethyl auristatin F)
ADC-AA-002 anti-HIgG(Fc)-C-MMAF ADC Cleavable linkers MMAF (Monomethyl auristatin F)
ADC-AA-001 anti-HIgG(Fc)-N-MMAF ADC Noncleavable linkers MMAF (Monomethyl auristatin F)
ADC-W-604 Anti-FUT3-Mc-VC-PABC-MMAF ADC-3 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F)
ADC-W-537 Anti-TPBG-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)

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