Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs is a pioneer company in antibody discovery and manufacture. With years of experience and professional scientists, we have established advanced agonistic antibody engineering platform for research, diagnostic and therapeutic use. Importantly, we are capable of offering a full package of biparatopic agonistic antibody engineering services for biological therapeutic development.
Bispecific antibodies (BsAb) represent new emerging antibody (Ab) -based therapeutics. Different from monoclonal antibody binding a single epitope site, BsAb are generally built with different antigen (Ag)-binding sites (Fab or single-chain Fv), each one used to provide a different target-binding specificity, albeit within the same molecule. They allow for potential synergy by engaging two separate targets or result in superior properties by engaging two epitopes on the same target. In addition, BaAb may enable new functions that are not possible to achieve with monospecific antibodies alone such as tissue-specific delivery or bringing cytotoxic T cells to tumor sites. What’s more, biparatopic agonistic antibody has been developed to simultaneously activate multicomponent receptor complexes.
Fig.1 Model for potential dual activities of some immune agonist antibodies. (Mayes, 2018)
Recently, several approaches based on traditional monoclonal antibody design and construction have been developed to generate a bispecific molecule. However, the custom random assembly of light chains and heavy chains may result in unwanted IgG species and thus lead to reduced yield of the correct product. To avoid this problem, the engineering of a single VH and VL pair to bind two different antigens has been developed. This bispecific format is constructed by using the antibody against the first antigen as the base to generate a library of light chain pairings which are then screened for their ability to bind a second antigen.
In addition, a unique approach that takes advantage of the properties of single-domain antibodies in therapeutic drug development has been developed for biparatopic agonistic antibody engineering. Using this method, BsAb is constructed by grafting two different antigen-specific VH domains onto the VH and VL positions of an IgG, yielding a tetravalent binder with two potential geometries, a close and a distant, between the two paratopes. What’s more, engineering biparatopic agonistic antibodies constructed by this approach have been proved have activities that are not observed when either paratope is targeted alone.
With years of experience and advanced technology platforms, Creative Biolabs is able to offer all the available approaches for biparatopic agonistic antibody engineering. With the extensive experience, abundant industry knowledge and advanced technical skills, our scientists are fully confident in accomplishing even the most challenging antibody engineering project to promote the development of your projects. For more detailed information, just feel free to contact us or directly send us a quote.
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