Biparatopic Antibody Development

What is Biparatopic Antibody?

Bispecific antibodies (BsAbs) are renowned for their capabilities of recognizing or binding to two or more antigens simultaneously, having focused great attention on immunotherapy in recent years. A diversity of BsAbs have been developed and pushed into clinical trials for the treatment of various human diseases, such as tumors, autoimmune diseases, hematological diseases, infections, etc. As a kind of engineered antibody, a diverse range of BsAb types have been created, such as tandem scFv, bibody, and single chain IgGs, among which biparatopic antibody is a special type that refers in particular to BsAb engineered to bind to two distinct epitopes on the same target. Biparatopic antibody has an enhanced binding to the target via antigen crosslinking and aggregation, exhibiting superior activities than each single paratope.

Fig. 1 Biparatopic antibody and its screening.¹

What Can We Do About Biparatopic Antibody?

Creative Biolabs has successfully finished hundreds of BsAb projects, covering from recombinant bsAb production and validation to one-stop BsAb development based on customers' specific needs. We have won a good reputation for delivering high-quality BsAb products and customized BsAb services. Benefiting from abundant BsAb project experience and a powerful technology platform, we are now launching biparatopic antibody development services to facilitate the advancement of BsAb drugs.

We can provide rapid recombinant biparatopic antibody production and purification service if you have a definite sequence of antibody variable regions. Otherwise, we also offer one-stop or tailored biparatopic antibody development services according to your demands, including but not limited to:

• Ascertainment of two single paratopes;
• Biparatopic antibody design and screening;
• Biparatopic antibody sequencing;
• Biparatopic antibody production and purification;
• Biparatopic antibody engineering and optimization;
• Biparatopic antibody characterization and functional validation.

Creative Biolabs has abundant project experience to offer sophisticated, canonical, and innovative BsAb, especially biparatopic antibody, development services tailored to customers' exact needs. Our technical staff are always ready online to provide professional and customized support and services. Any question or demand about bispecific antibody products and services, just feel free to contact us or directly send us an inquiry.