BsAb Engineering
Over the past decades, the three antibody generation strategies, chemical conjugation, hybrid hybridomas and genetic engineering have resulted in over 67-70 different formats of bispecific antibodies. These BsAbs have been widely researched in diagnostic and therapeutic fields. We can provide BsAb engineering service to adjust the properties of BsAbs such as valency, size, half-life, flexibility, etc., to meet the specific requirements.


Home > SERVICES > Bispecific Antibody (BsAb) Engineering

Creative Biolabs offers specialized bispecific antibody (BsAb) engineering services, providing tailored solutions for different formats of BsAb generation through strategies like hybridomas, genetic engineering, and chemical conjugation techniques. Our comprehensive services include design, expression, purification, and characterization, ensuring the development of high-performance BsAbs. With rapid turnaround times and expert support, we help you create potent, targeted therapies for a wide range of diseases.

Bispecific IgGs. (Creative Biolabs Original)
Bispecific IgGs
Bispecific IgGs resemble conventional IgG antibodies but are engineered to possess including "knobs-into-holes" technology, which promotes heterodimerization of heavy chains, and CrossMAb technology, which swaps domains between heavy chains. These methods are crucial for minimizing mispairing and ensuring functional BsAb production. Bispecific IgGs retain the Fc region, enabling effector functions like CDC and ADCC.
Learn More
Bispecific Antibody (BsAb) Fragments
BsAb fragments are smaller, engineered antibody fragments designed for bispecificity. Common examples include scFvs (single-chain variable fragments) and diabodies. Their reduced size enhances tumor penetration and allows for rapid clearance. However, they lack the Fc region, eliminating Fc-mediated effector functions and often resulting in shorter serum half-lives.
Learn More
Bispecific antibody (BsAb) fragments. (Creative Biolabs Original)
Bispecific fusion proteins. (Creative Biolabs Original)
Bispecific Fusion Proteins
Bispecific Fusion Proteins involve genetically linking two distinct antibody fragments or other protein domains with different specificities. Fusion proteins, with flexibility in combining diverse functionalities, can incorporate antibody domains with other proteins, such as cytokines or enzymes, enabling targeted therapy combined with immunomodulation. The linker's length and composition can influence the BsAb's stability and activity.
Learn More
Bispecific Antibody (BsAb) Conjugates
BsAb conjugates are created by chemically conjugating two distinct antibodies or antibody fragments. This approach offers a straightforward way to combine pre-existing antibodies with desired specificities. Conjugation methods, such as disulfide bridges or chemical linkers, must be carefully optimized to maintain the activity and stability of the resulting BsAb. This method is often used to combine antibodies that are already well characterized.
Learn More
Bispecific antibody (BsAb) conjugates. (Creative Biolabs Original)
Fc engineering in bispecific antibody (BsAb). (Creative Biolabs Original)
Fc Engineering in Bispecific Antibody (BsAb)
The Fc region of IgG antibodies plays a critical role in mediating effector functions and determining serum half-life. Fc engineering allows for precise control over these properties. Modifications can enhance or abrogate Fc-mediated effector functions, such as ADCC and CDC, depending on the therapeutic goal. For example, mutations can be introduced to enhance binding to Fcγ receptors, boosting ADCC, or to eliminate Fcγ receptor binding, reducing unwanted immune activation. Additionally, Fc modifications can extend serum half-life, improving the pharmacokinetic profile of BsAbs.
Learn More
Focus on Bispecific Antibody, Focus on Creative Biolabs

Novel Platforms Facilitate Innovative and Efficient BsAb Development

SERVICES

PRODUCTS

PLATFORMS

quality
ISO 9001 Certified - Creative Biolabs Quality Management System.
© 2025 Creative Biolabs. All Rights Reserved.