Creative Biolabs provides professional appended BsIgG design, construction and analysis services for your research. We have been committed to offering customers an impeccable antibody engineering platform based on brilliant technical scientists, advanced protein engineering techniques and a reliable and robust construction system which can meet each customer’s individual requirements.
Bispecific antibodies (BsAb) are artificial antibodies that bind two different antigens, or two different epitopes on the same antigen. Engineering of BsAbs opens up many new potential therapeutic applications from the fields of immunotherapy, chemotherapy, radiotherapy, and gene therapy. Appended IgGs are a group of BsAb structural groups of which conventional IgGs are appended with one or more additional antigen-binding units. That is, in appended IgGs, monospecific IgGs are engineered for bispecificity by add additional antigen-binding moieties to either the carboxy or amino termini of either heavy or light chains. The antigen-binding moieties may be Fab, scFv, Fv, single domain antibodies or engineered protein scaffolds. To produce different formats of appended IgGs, genetic engineering is the most widely used and appropriate method.
For now, there have been numerous of appended BsIgGs researched and reported, some of which have reached clinical development. The main formats of appended IgGs are listed below.
According to every client’s requirements, Creative Biolabs provides customized BsAb engineering services. For more detailed information, please feel free to contact us or directly send us an online inquiry.
Spiess, C.; et al. Alternative molecular formats and therapeutic applications for bispecific antibodies. Molecular immunology. 2015, 67(2): 95-106.