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Magic™ Antibody Discovery - Mouse Integrin alpha V beta 8 (31-988(ITGAV)&22-681(ITGB8)) Membrane Protein, Partial, His Tag & Tag free (CAT#: MP0230F)

Datasheet
This membrane protein is Mouse Integrin alpha V beta 8 (31-988(ITGAV)&22-681(ITGB8)). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • Integrin alpha V beta 8
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 112.5 kDa (ITGAV) and 77.5 kDa (ITGB8). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB8 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 130-150 kDa (ITGAV) and 80-90 kDa (ITGB8) respectively due to glycosylation.
  • Sequence
  • AA Phe 31 - Val 988 (ITGAV) & Gly 22 - Leu 681 (ITGB8) (Accession # P43406-1 (ITGAV) & Q0VBD0-1 (ITGB8)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a His tag & subunit ITGB8 contains no tag but a basic tail at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Integrin alpha V beta 8
  • Full Name
  • integrin subunit alpha V&integrin subunit beta 8
  • Introduction
  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.& This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
  • Alternative Names
  • CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik; integrin alpha-V; alpha v integrin; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha&4832412O06Rik; integrin beta-8

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