Magic™ Membrane Protein Human CDH10 (Cadherin 10) Expressed in CHO for Antibody Discovery, Partial (23-613aa) (CAT#: MPX0409K)

Datasheet

This product is a 92.7 kDa Human CDH10 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
CDH10

Protein Length
Partial (23-613aa)

Protein Class
Cell adhesion

Molecular Weight
92.7 kDa

Sequence
EIMFRRTPVPQQRILSSRVPRSDGKILH
RQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGT
LFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKI
HDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIY
SILQGQPYFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLS
GTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGK
NAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEA
ENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVG
TIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRE
LSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCEN
ARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTR
KNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSA
EALLLPAGLSTGA

Product Description

Activity
Yes

Expression Systems
CHO

Tag
hIgG1 Fc tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.

Endotoxin
<0.01 EU per 1 μg of the protein by the LAL method.

Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
CDH10

Full Name
Cadherin 10

Introduction
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients.

Alternative Names
CDH10; cadherin-10; T2-cadherin; cadherin 10 type 2; Cadherin 10

Gene ID
1008

UniProt ID
Q9Y6N8

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