Magic™ Membrane Protein Human HLA-DQA1 (Major histocompatibility complex, class II, DQ alpha 1) Expressed in E.coli with 6xHis tag at the N-terminus for Antibody Discovery, Partial (24-213aa) (CAT#: MPX4453K)

Datasheet

This product is a 25.4kDa Human HLA-DQA1 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
HLA-DQA1

Protein Length
Partial (24-213aa)

Protein Class
Immunity

Molecular Weight
25.4kDa

Sequence
EDIVADHVASYGVNLYQSYGPSGQYTHEFDGDEQFYVDLGRKETVWCLPVLRQFRFDPQFALTNIAVLKHNLNSLIKRSNSTAATNEVPEVTVFSKSPVTLGQPNILICLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTLLPSAEESYDCKVEHWGLDKPLLKHWEPEIPAPMSE

Product Description

Expression Systems
E.coli

Tag
6xHis tag at the N-terminus

Protein Format
Soluble

Purity
>90% as determined by SDS-PAGE

Buffer
Tris-based buffer, 50% glycerol

Target

Target Protein
HLA-DQA1

Full Name
Major histocompatibility complex, class II, DQ alpha 1

Introduction
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Alternative Names
HLA-DQA1; DQA1; DQ-A1; CELIAC1; HLA-DQA; HLA class II histocompatibility antigen, DQ alpha 1 chain; DC-1 alpha chain; DC-alpha; HLA class II histocompatibility antigen DQ alpha chain; HLA-DCA; MHC HLA-DQ alpha; MHC class II DQ alpha chain; MHC class II DQA1; MHC class II HLA-DQ-alpha-1; MHC class II antigen DQA1; MHC class II protein; truncated MHC class II antigen; Major histocompatibility complex, class II, DQ alpha 1

Gene ID
3117

UniProt ID
P01909

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