Creative Biolabs is committed to providing first-class VLP-related products and services. Relied on our innovative technology, we have extensive experience in assembling a variety of VLP products based on our advanced mammalian cells system and insect system, also labeled with Green Fluorescent Protein (GFP).
Virus-like particles (VLPs) are composed of one or more structural proteins/capsid proteins of viruses by self-assembling into a particular spatial conformation. VLPs maintain the same structural properties as virions, without a genome. These constructs are considered very efficient as vaccine platforms and therapeutic delivery systems. VLPs also have similar characteristics as nanomaterials and have the ability to mediate more biomedical functions through biotechnological methods. Therefore, VLPs have a significant function in drug delivery, genetic therapy, cellular targeting, and cancer treatment.
Middle East respiratory syndrome (MERS) is a viral respiratory disease. It is a positive-sense, single-stranded RNA virus with a genome encodes four major structural proteins spike (S), envelope (E), membrane (M), and nucleocapsid (N), as well as non-structural proteins (nsp1–16) translated from open reading frames (ORFs) 1a and 1b, and several accessory proteins, such as 3, 4a, 4b, 5, and 8b. So Far, Creative Biolabs has successfully created VLP products composed of S, M, and E or S, M, N, E in mammalian cells and/or insect cell expression systems (baculovirus). Moreover, we have extensive experience in VLPs labeled with GFP.
Fig.1 Schematic structures of MERS-CoV genome.1
Creative Biolabs provides end-to-end comprehensive VLP management services from synthesis to characterization. Creative Biolabs has established multiple comprehensive platforms to provide customized VLPs production services, including E. coli expression system, yeast expression system, insect cells expression system and mammalian cells expression system. After years of dedication, we can provide an all-around service package from initial construct design, synthesis, cloning transfection, expression, harvest, purification (e.g. soluble, insoluble) and characterization (e.g. biological, biochemical, biophysical). Our core values are driven by a desire to help our clients achieve scientific excellence and operate with the highest standards of integrity. Please don't hesitate to contact us for further discussions.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.