Get a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
In Vitro-Transcribed (IVT) CAR
As one of the most promising adoptive immunotherapy for cancer, CAR-T therapy has achieved good therapeutic efficacy in antitumor therapy. However, due to current CAR T cell engineering is usually mediated via viral vectors that induce permanent CAR expression, there are safety concerns of permanent mutagenesis. In order to circumvent risk, in vitro-transcribed (IVT)-mRNA-mediated transfection is an attractive tool for rapid, facile, and safe CAR production. Based on the most advanced technology and years of experience, Creative Biolabs is dedicated to delivery of the state-of-the-art CAR therapies. our R&D scientists provide a one-stop CAR IVT products and services including IVT plasmid, IVT mRNA, and IVT LNP.
CAR IVT Plasmid Products
Creative Biolabs provides a one-stop solution for the development of CAR IVT products. Our IVT plasmid manufacturing workflow contains codon optimization, gene synthesis, vector design, and vector cloning, with many customizable options. Our team of experts provides professional support and technological guidance in each plasmid DNA production program, to make sure optimal plasmid production. A series of rigorous QC assays are performed to ensure the plasmid DNA template is optimal for downstream mRNA manufacturing. Based on extensive design and project experience, we have a high success rate using the IVT system. Working with us can help accelerate your project significantly.
Fig.1 Schematic overview of the synthesis of IVT mRNA. (Steinle, et al., 2017)
Browse the following CAR IVT plasmids we provide.
Custom Services
Creative Biolabs provides a service for the custom CAR IVT plasmids. If you do not find the desired products, please contact us. Simply provide us with the desired sequence data and we will generate a high IVT plasmid.
Fig.2 Workflow of CAR IVT plasmid production. (Creative Biolabs)
Reference
Associated Antigen Target
NEWSLETTER
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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