varlilumab

Cat

TAB-H74

Product Overview

Recombinant human antibody to Human CD27. Varlilumab is an immunotherapy designed to enhance the body's natural immune response by directly activating T cells that can specifically recognize and kill cancer cells.

Type

IgG1 - kappa

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, ICC and most other immunological methods.

Specificity

CD27 (TNFRSF7, tumor necrosis factor receptor superfamily member 7) [Homo sapiens]

Purity

>95%, by SDS-PAGE with silver staining, under reducing conditions.

Antigen Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor

Function

cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; receptor activity; transmembrane signaling receptor activity;

Gene ID

939

Synonyms

CD27; CD27 molecule; TNFRSF7, tumor necrosis factor receptor superfamily, member 7; CD27 antigen; S152; Tp55; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7; T14; TNFRSF7; MGC20393;

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