Ixekizumab

Cat

TAB-217

Product Overview

Recombinant monoclonal antibody to IL17RA. Ixekizumab is a humanized monoclonal antibody used in the treatment of autoimmune diseases.

Target

IL17RA

Type

IgG4 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in WB, IP, IF, FuncS, FC, Neut, ELISA and most other immunological methods.

CAS

1143503-69-8

Specificity

Tested positive against native human antigen.

Protein Construction

Immunoglobulin G4, anti-(human interleukin 17A) (human monoclonal LY2439821 γ4-chain), disulfide with human monoclonal LY2439821 kappa-chain, dimer

Predicted N terminal

H chain: QVQLVQS; L chain: DIVMTQT

Molecular Weight

146200

Purity

Purity >95% by SDS-PAGE.

Size

1mg

Storage

Store at -20°C. Avoid multiple freeze/thaw cycles.

Antigen Description

Interleukin 17 Receptor Alpha is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.

Function

interleukin-17 receptor activity; receptor activity;

Gene ID

23765

Synonyms

IL17RA; interleukin 17 receptor A; IL17R, interleukin 17 receptor; interleukin-17 receptor A; CD217; CDw217; hIL 17R; IL 17RA; IL-17 receptor A; IL17R; CANDF5; IL-17RA; hIL-17R; FLJ32274; FLJ36453; MGC10262;

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