ADC Linker Products

Product Overview Related Services Scientific Resources Quick Links Product List

Product Overview

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

ADC Linker Services

Creative Biolabs offers a comprehensive "DrugLnk" linker module designed to cater to the diverse needs of antibody-drug conjugate (ADC) development. This module focuses on the design and preparation of various types of linkers, tailored to their specific drug release mechanisms. Clients can choose from a range of linker types:

Leveraging an advanced synthetic chemistry platform along with an extensive inventory of toxins, linkers, and drug-linker sets, "DrugLnk" at Creative Biolabs enables our skilled chemists to provide specialized services.

(1) Design linkers with optimal size
(2) Select linkers with suitable release mechanism
(3) Engineer linkers with compatible conjugation chemistry
(4) Synthesize customized linkers
(5) Modify payload drug
(6) Design synthesis routes
(7) Synthesize customized drug-linker complexes

Please feel free to contact us for more information about our ADC linker services.

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

Global Antibody-drug Conjugate (ADC) Clinical Trial ReviewGlobal Antibody-drug Conjugate (ADC) Clinical Trial Review 2018.3

Creative Biolabs ADC Product Brochure

Protocol

Quick Links

ADC Toxins

Drug-linker Complexes

Customized ADCs

Anti-Ab ADCs

Product List

Catalog	Product name	CAS NO	Structure	Molecular Weight	Purity	Data sheet	Inquiry
ADC-L-063	N-succinimidyl-5-(2-pyridyldithio)valerate	317331‐86‐5		340.42	95%		Inquiry
ADC-L-064	N-succinimidyl-6-(2-pyridyldithio)capronate	1824718-79-7		354.44	95%		Inquiry
ADC-L-065	SPDP-C6-NHS ester	158913-22-5		425.5	95%		Inquiry
ADC-L-066	4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene	112241-19-7		388.46	95%		Inquiry
ADC-L-067	4-succinimidyl-oxycarbonyl-α-(2-pyridyldithio)toluene	160854-54-6		374.43	95%		Inquiry
ADC-L-068	15-(2-pyridyldithio)-4,7,10,13-tetraoxapentadecanoic acid N-hydroxysuccinimide ester	1305053-43-3		488.57	95%		Inquiry
ADC-L-069	4-Nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate	874302-76-8		352.39	95%		Inquiry
ADC-L-070	4-Nitrophenyl 2-(pyridin-2-yldisulfanyl)propyl carbonate			366.41	95%		Inquiry
ADC-L-071	2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate			380.44	95%		Inquiry
ADC-L-072	N-SMP	55750‐61‐3		252.18	95%		Inquiry
ADC-L-073	3-(Maleimido)propionic acid N-hydroxysuccinimide ester	55750-62-4		266.21	95%		Inquiry
ADC-L-074	GMBS	80307-12-6		280.23	95%		Inquiry
ADC-L-075	5-Maleimido-pentanoic NHS ester	103750-03-4		294.3	95%		Inquiry
ADC-L-076	Mal-PEG2-NHS ester	1433997-01-3		354.3	95%		Inquiry
ADC-L-077	Mal-PEG4-PFP	1415800-42-8		511.4	95%		Inquiry
ADC-L-078	Mal-PEG4-NHS ester	1325208-25-0		442.4	95%		Inquiry
ADC-L-079	perfluorophenyl 1-(2,5-dioxo-2H-pyrrol-1(5H)-yl)-3,6,9,12-tetraoxapentadecan-15-oate	1415800-42-8		511.39	95%		Inquiry
ADC-L-080	Mal-PEG-NHS	1260092-50-9		381.34	95%		Inquiry
ADC-L-081	Mal-amido-PEG2-NHS	955094-26-5		425.4	95%		Inquiry
ADC-L-082	Mal-amido-PEG4-NHS	756525-99-2		513.5	95%		Inquiry