Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.
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| Catalog |
Product name |
CAS NO |
Structure |
Molecular Weight |
Purity |
Data sheet |
Inquiry |
| ADC-L-123 |
2,5-dioxo-1-(3-(pyridin-2-yldisulfanyl)propanoyloxy)pyrrolidine-3-sulfonic acid |
121115-30-8 |
 |
392.43 |
95% |
 |
Inquiry |
| ADC-L-124 |
N-succinimidyl 4-(5-nitro-pyridin-2-yldithio)-pentanoate |
663598-85-4 |
 |
371.39 |
95% |
|
Inquiry |
| ADC-L-125 |
2,5-dioxopyrrolidin-1-yl 4-((5-(dimethylcarbamoyl)pyridin-2-yl)disulfanyl)butanoate |
663599-05-1 |
 |
397.47 |
95% |
|
Inquiry |
| ADC-L-126 |
N-Succinimidyloxycarbonylpropyl Methanethiosulfonate |
690632-55-4 |
 |
295.33 |
95% |
|
Inquiry |
| ADC-L-127 |
3-(methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)butanoate |
890409-86-6 |
 |
449.48 |
95% |
|
Inquiry |
| ADC-L-128 |
1-(4-((5-nitropyridin-2-yl)disulfanyl)butanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid |
663598-89-8 |
 |
451.45 |
95% |
|
Inquiry |
| ADC-L-129 |
1-(4-((5-(dimethylcarbamoyl)pyridin-2-yl)disulfanyl)butanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid |
663599-07-3 |
 |
477.53 |
95% |
|
Inquiry |
| ADC-L-130 |
2,5-dioxopyrrolidin-1-yl 2-(dimethylamino)-4-(pyridin-2-yldisulfanyl)butanoate |
1193111-73-7 |
 |
369.46 |
95% |
|
Inquiry |
| ADC-L-131 |
1-((4-((5-Nitropyridin-2-yl)disulfanyl)pentanoyl)oxy)-2,5-dioxopyrrolidine-3-sulfonic acid |
663598-66-1 |
 |
465.48 |
95% |
|
Inquiry |
| ADC-L-132 |
1-(4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid |
663599-00-6 |
 |
479.51 |
95% |
|
Inquiry |
| ADC-L-133 |
sulfo-LC-SPDP |
150244‐18‐1 |
 |
505.59 |
95% |
|
Inquiry |
| ADC-L-134 |
2,5-dioxopyrrolidin-1-yl 3-oxo-1-(pyridin-2-yldisulfanyl)-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oate |
1252257-56-9 |
 |
735.86 |
95% |
|
Inquiry |
| ADC-L-135 |
N-Maleimidobutyryloxysulphosuccinimide este |
158018-81-6 |
 |
360.29 |
95% |
|
Inquiry |
| ADC-L-136 |
6-Maleimidocaproic acid sulfo-NHS |
103848-61-9 |
 |
388.35 |
95% |
|
Inquiry |
| ADC-L-137 |
1-((1r,4r)-4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarbonyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid |
|
 |
414.38 |
95% |
|
Inquiry |
| ADC-L-138 |
(S)-2-((S)-2-(6-(2,5-dioxo-2H-pyrrol-1(5H)-yl)hexanamido)-3-methylbutanamido)propanoic acid |
1342211-31-7 |
 |
381.42 |
95% |
|
Inquiry |
| ADC-L-139 |
Mal-PEG2-PFP |
1807512-47-5 |
 |
423.3 |
95% |
|
Inquiry |
| ADC-L-140 |
2,5-dioxopyrrolidin-1-yl 2-(2-(2-(2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)ethoxy)ethoxy)acetate |
|
 |
384.34 |
95% |
|
Inquiry |
| ADC-L-141 |
Mal-NH-PEGn-CH2CH2COOPFP Ester |
1347750-81-5 |
 |
494.37 |
95% |
|
Inquiry |
| ADC-L-142 |
2,5-dioxopyrrolidin-1-yl 15-(2,5-dioxo-2H-pyrrol-1(5H)-yl)-13-oxo-3,6,9-trioxa-12-azapentadecan-1-oate |
|
 |
455.42 |
95% |
|
Inquiry |
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