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ADC Linker Products

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Product Overview

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

ADC Linker Services

Creative Biolabs offers a comprehensive "DrugLnk" linker module designed to cater to the diverse needs of antibody-drug conjugate (ADC) development. This module focuses on the design and preparation of various types of linkers, tailored to their specific drug release mechanisms. Clients can choose from a range of linker types:

Leveraging an advanced synthetic chemistry platform along with an extensive inventory of toxins, linkers, and drug-linker sets, "DrugLnk" at Creative Biolabs enables our skilled chemists to provide specialized services.

(1) Design linkers with optimal size
(2) Select linkers with suitable release mechanism
(3) Engineer linkers with compatible conjugation chemistry
(4) Synthesize customized linkers
(5) Modify payload drug
(6) Design synthesis routes
(7) Synthesize customized drug-linker complexes

Please feel free to contact us for more information about our ADC linker services.

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
Global Antibody-drug Conjugate (ADC) Clinical Trial ReviewGlobal Antibody-drug Conjugate (ADC) Clinical Trial Review 2018.3
Development of Monoclonal Antibodies
Creative Biolabs ADC Product Brochure
CAMouse™-Fully Human Antibody Generation Platform
Protocol

Quick Links

ADC Toxins
Drug-linker Complexes
Customized ADCs
Anti-Ab ADCs

Product List

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Catalog Product name CAS NO Structure Molecular Weight Purity Data sheet Inquiry
ADC-L-103 2,5-Dioxopyrrolidin-1-yl 3-(2-(4-formylbenzamido)ethoxy)propanoate 2,5-Dioxopyrrolidin-1-yl 3-(2-(4-formylbenzamido)ethoxy)propanoate 362.33 95% Inquiry
ADC-L-104 Perfluorophenyl 3-(2-(2-(4-formylbenzamido)ethoxy)ethoxy)propanoate Perfluorophenyl 3-(2-(2-(4-formylbenzamido)ethoxy)ethoxy)propanoate 475.36 95% Inquiry
ADC-L-105 2,5-dioxopyrrolidin-1-yl 3-(2-(2-(4-formylbenzamido)ethoxy)ethoxy)propanoate 1807521-07-8 2,5-dioxopyrrolidin-1-yl 3-(2-(2-(4-formylbenzamido)ethoxy)ethoxy)propanoate 406.39 95% Inquiry
ADC-L-107 2,3,4,5,6-pentafluorophenyl 3-[2-(2-{2-[(4-formylphenyl)formamido]ethoxy}ethoxy)ethoxy]propanoate 2,3,4,5,6-pentafluorophenyl 3-[2-(2-{2-[(4-formylphenyl)formamido]ethoxy}ethoxy)ethoxy]propanoate 519.42 95% Inquiry
ADC-L-108 Ald-Ph-PEG4-NHS ester 1353011-74-1 Ald-Ph-PEG4-NHS ester 494.5 95% Inquiry
ADC-L-109 tert-butyl 1-(4-formylphenyl)-1-oxo-5,8,11-trioxa-2-azatridecan-13-oate 1007215-94-2 tert-butyl 1-(4-formylphenyl)-1-oxo-5,8,11-trioxa-2-azatridecan-13-oate 395.45 95% Inquiry
ADC-L-110 4-formyl-N-(2-(2-hydroxyethoxy)ethyl)benzamide 1061569-06-9 4-formyl-N-(2-(2-hydroxyethoxy)ethyl)benzamide 237.25 95% Inquiry
ADC-L-111 Ald-Ph-PEG4-acid 1309460-27-2 Ald-Ph-PEG4-acid 397.4 95% Inquiry
ADC-L-112 2-(4-formylbenzamido)ethyl nitrate  141534-26-1 2-(4-formylbenzamido)ethyl nitrate 238.19 95% Inquiry
ADC-L-113 2,5-dioxopyrrolidin-1-yl 3-(2-(2-(1,3-dioxoisoindolin-2-yloxy)ethoxy)ethoxy)propanoate 2,5-dioxopyrrolidin-1-yl 3-(2-(2-(1,3-dioxoisoindolin-2-yloxy)ethoxy)ethoxy)propanoate 420.37 95% Inquiry
ADC-L-114 perfluorophenyl 3-(2-(2-(2-(1,3-dioxoisoindolin-2-yloxy)ethoxy)ethoxy)ethoxy)propanoate perfluorophenyl 3-(2-(2-(2-(1,3-dioxoisoindolin-2-yloxy)ethoxy)ethoxy)ethoxy)propanoate 533.4 95% Inquiry
ADC-L-115 perfluorophenyl 3-(2-(2-(1,3-dioxoisoindolin-2-yloxy)ethoxy)ethoxy)propanoate perfluorophenyl 3-(2-(2-(1,3-dioxoisoindolin-2-yloxy)ethoxy)ethoxy)propanoate 489.35 95% Inquiry
ADC-L-116 2,5-Dioxopyrrolidin-1-yl 1-(1,3-dioxoisoindolin-2-yloxy)-3,6,9,12-tetraoxapentadecan-15-oate 1415328-95-8 2,5-Dioxopyrrolidin-1-yl 1-(1,3-dioxoisoindolin-2-yloxy)-3,6,9,12-tetraoxapentadecan-15-oate 508.48 95% Inquiry
ADC-L-117 perfluorophenyl 1-(1,3-dioxoisoindolin-2-yloxy)-3,6,9,12-tetraoxapentadecan-15-oate perfluorophenyl 1-(1,3-dioxoisoindolin-2-yloxy)-3,6,9,12-tetraoxapentadecan-15-oate 577.45 95% Inquiry
ADC-L-118 Bis-PEG1-NHS ester 65869-64-9 Bis-PEG1-NHS ester 356.3 95% Inquiry
ADC-L-119 Bis-PEG2-NHS ester 65869-63-8 Bis-PEG2-NHS ester 400.3 95% Inquiry
ADC-L-120 Bis-PEG3-NHS ester 1314378-16-9 Bis-PEG3-NHS ester 444.4 95% Inquiry
ADC-L-121 Bis-PEG4-NHS ester 1314378-11-4 Bis-PEG4-NHS ester 488.5 95% Inquiry
ADC-L-122 2,5-dioxopyrrolidin-1-yl 1-(2,5‐dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18-hexaoxahenicosan-21-oate 2,5-dioxopyrrolidin-1-yl 1-(2,5‐dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18-hexaoxahenicosan-21-oate 95% Inquiry
ADC-L-123 2,5-dioxo-1-(3-(pyridin-2-yldisulfanyl)propanoyloxy)pyrrolidine-3-sulfonic acid 121115-30-8 2,5-dioxo-1-(3-(pyridin-2-yldisulfanyl)propanoyloxy)pyrrolidine-3-sulfonic acid 392.43 95% Inquiry
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