Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsEMSA is a biochemical procedure for characterizing protein-nucleic acid interaction (PNI). Nucleic acid fragments are often labeled for visualization purposes. In a classical assay, labeled nucleic acid and test protein are incubated, and the resulting mixture is subjected to electrophoresis. Since the molecular mass of the complex formed increases, the mobility of the complex decreases during this process. Since nucleic acid contains some special markers, the distribution of the substance can be determined by various methods, thereby proving the PNI. With the advancement of experimental technology, the assay can perform qualitative and quantitative analyses of the target.
Fig.1 The schematic illustration of EMSA. (Song, 2015)
EMSA is a popular in vitro method for detecting PNI. In addition to detecting transcription factors, this technique plays a crucial role in DNA-protein interactions, RNA-protein interactions and even DNA-RNA interactions. At Creative Biolabs, we offer specialized EMSA services to efficiently and accurately identify potential PNI.
During this assay, we add specific antibodies that recognize the protein of interest to the mixture to generate complexes with greater displacement. This method allows the identification of proteins present in the complex.
Running additional lanes with competing oligonucleotides is an effective strategy for determining the most favorable binding sequence of the binding protein. Furthermore, variants of MC-EMSA are powerful tools for measuring the specificity of binding as well as the measurement of association and dissociation kinetics.
Fig.2 The workflow of EMSA. (Creative Biolabs)
Fig.3 Our advantages. (Creative Biolabs)
At Creative Biolabs, we conduct strict quality inspections on both the nucleotides and proteins to be tested to ensure the smooth progress of EMSA experiments. Our advanced signal detection instruments guarantee high sensitivity and high signal-to-noise ratio results. Please contact us in time to obtain professional EMSA service solutions. Our seasoned scientists are ready to start your project.
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