Asparagus cochinchinensis-derived Exosome Research and Application

Creative Biolabs introduces research and applications of exosomes derived from Asparagus cochinchinensis to our clients. This presents an exciting opportunity to explore the biomedical potential of plant-derived exosomes, with a focus on cancer treatment and drug delivery, offering a novel and promising field for research and development.

The Value of Asparagus cochinchinensis

Asparagus cochinchinensis is a highly valuable medicinal and edible plant, known for its various benefits, including but not limited to:

Antioxidant and Anti-Aging Properties: Asparagus cochinchinensis is rich in natural polysaccharides and amino acids with strong antioxidant capabilities. These components can neutralize free radicals, reduce oxidative stress, delay cell aging, and prevent chronic diseases. It also enhances the body's antioxidant capacity, contributing to overall health and vitality.
Respiratory Health Support: Moderate consumption of Asparagus cochinchinensis can help maintain lung tissue and alleviate respiratory discomfort such as dry cough and phlegm, promoting respiratory system health.
Antibacterial and Anti-Inflammatory Effects: Asparagus cochinchinensis possesses antibacterial and anti-inflammatory characteristics, making it potentially valuable in preventing and treating various infectious diseases. In clinical settings, it has shown significant efficacy in some inflammatory conditions.
Cardioprotection and Liver Health: Active compounds in Asparagus cochinchinensis may help protect the heart muscle and maintain liver health. It helps maintain stable blood pressure and lipid levels, promoting cardiovascular health.
Anti-Cancer Effects: Some active components in Asparagus cochinchinensis, such as polysaccharides and antioxidants, have shown potential benefits in cancer prevention and treatment. While specific mechanisms require further research, evidence suggests that Asparagus cochinchinensis may combat cancer through immune modulation, anti-inflammation, and antioxidation.

Research on Asparagus cochinchinensis-derived Exosome

Plant exosomes, or plant extracellular vesicles, are small vesicles secreted by plant cells that share similarities with animal cell exosomes. They play crucial roles in intercellular communication and material transfer. Therefore, exosomes derived from Asparagus cochinchinensis may encapsulate bioactive molecules with properties like antioxidation, anti-cancer, and antibacterial effects. These exosomes can serve as drug delivery systems, precisely delivering these active ingredients to disease sites, enhancing drug bioavailability, and treatment effectiveness.

Title: Engineering exosome-like nanovesicles derived from Asparagus cochinchinensis can inhibit the proliferation of hepatocellular carcinoma cells with a better safety profile.

Research Methods:

Successful isolation and purification of exosomes derived from Asparagus cochinchinensis using differential centrifugation and sucrose density gradient ultracentrifugation methods.
Evaluation of the cytotoxicity, anti-proliferation, and apoptosis-inducing capabilities of Asparagus cochinchinensis-derived exosomes on human hepatocellular carcinoma cells.
In vivo distribution of Asparagus cochinchinensis-derived exosomes in healthy and tumor-bearing mice, with a specific focus on scavenger receptors (SRs) impact.
PEG modification of Asparagus cochinchinensis-derived exosomes to optimize pharmacokinetic properties.
Assessment of in vivo anti-tumor activity and toxicity of PEG-modified Asparagus cochinchinensis-derived exosomes using a human hepatocellular carcinoma xenograft mouse model.

Research Findings:

Asparagus cochinchinensis-derived exosomes exhibit specific anti-proliferation activity against cancer cells, associated with an apoptosis-inducing pathway.
Blocking SRs or PEG modification extends the circulation time of Asparagus cochinchinensis-derived exosomes in the bloodstream and increases their accumulation at tumor sites.
PEG-modified Asparagus cochinchinensis-derived exosomes effectively inhibit tumor growth in vivo with minimal side effects.

Conclusion: Exosomes extracted from Asparagus cochinchinensis demonstrate significant anti-tumor activity, especially when modified with PEG, prolonging circulation time and enhancing accumulation at tumor sites while causing minimal side effects. This research provides a promising approach for liver cancer treatment using Asparagus cochinchinensis-derived exosomes, with significant clinical application potential.

Fig.1 In vivo antitumor efficacy of Asparagus cochinchinensis-derived exosome in Hep G2 tumor xenograft nude mice.¹

Plant Exosome Development Capabilities

Creative Biolabs offers an advanced plant exosome development platform, providing researchers and clients with a powerful tool to explore the potential applications and functions of plant-derived exosomes in greater depth. If you have research needs related to exosomes derived from Asparagus cochinchinensis or other medicinal plants, please contact us to learn about feasible support and solutions.

Plant-Derived Exosome Isolation

Plant-Derived Exosome Identification

High-Throughput Screening Analysis (Proteins, RNA, Lipids and Metabolites)

Target Analysis

In Vitro Functional Discovery of Plant-Derived Exosomes

In Vivo Functional Discovery of Plant-Derived Exosomes

Large-Scale Production of Plant-Derived Exosomes

Reference

Zhang, L.; He, F.; et al. Engineering exosome-like nanovesicles derived from Asparagus cochinchinensis can inhibit the proliferation of hepatocellular carcinoma cells with better safety profile. International Journal of Nanomedicine. 2021, 16:1575-1586.

Plant Exosome Isolation