Production Efficiency Evaluation Service for Exosome Product
As an efficient means of intercellular communication, exosomes (Exos) have a wide range of biological functions and medical potential. Therefore, more and more researchers are developing Exos as an important biological product. As the research and application of Exos gradually deepen, the requirements for the quality and productivity of Exo products are also getting higher and higher. As a professional biotechnology company, Creative Biolabs has rich experience and a professional technical team to provide high-quality evaluation services for the productivity of Exo products.
Fig. 1 The schematic illustration of drug-loaded exosome process steps. (Kimiz-Gebologlu, 2022)
Reasons for Evaluating Productivity of Exosome (Exo) Product
The production and purification process of Exos is complex and requires multiple steps, including cell culture or biological fluid collection, concentration, centrifugation, identification, etc. These steps require high technical requirements for operation, which can easily affect the quality and output of the product. Therefore, evaluating the productivity of Exo products helps customers control product quality, and cost and improve product development efficiency and competitiveness.
Productivity Evaluation Service of Exo Product at Creative Biolabs
In order to ensure the quality and productivity of Exo products, Creative Biolabs comprehensively evaluates the productivity from the following aspects to help customers obtain rigorous data or optimize the production process.
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Biological fluid collection efficiency. The yield of cell culture supernatant and biological fluid is mainly affected by factors such as operators, cell types, culture conditions, and culture scale. Our professionals help customers evaluate the collection of biological fluids and provide optimization solutions. We also provide standardized and high-quality large-scale cell culture service.
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Exo isolation efficiency. The isolation method should be evaluated in terms of throughput, time required, and Exo yield. Traditional Exo extraction methods are time-consuming and laborious and are only suitable for the preliminary research stage. However, the use of ultrafiltration devices to concentrate large quantities of biological fluids before extraction can increase throughput and improve separation efficiency. In addition, with the deepening of Exo research and the continuous development of technology, efficient and fully automatic Exo isolation systems are also emerging, which is expected to meet the demand for a large number of Exo products in later trials. We especially introduce the pretreatment service of tangential flow filtration and automatic extraction service to solve customers' difficulties.
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Exo identification efficiency. A more efficient Exo identification system is needed to improve the efficiency of Exo identification in the production process. It is exciting that the emergence of nano flow cytometry meets the simultaneous and rapid detection of Exo particle size and marker proteins. This technology is necessary to be used in the downstream process of Exo production. It just so happens that we provide nano flow cytometric detection of Exos.
Through systematic analysis and optimization of each link in the production of Exos, we help customers improve the productivity of Exo products and reduce production costs. If you need to evaluate and optimize the productivity of Exo products, please contact us.
Reference
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Kimiz-Gebologlu, I.; Oncel, SS.; et al. Exosomes: large-scale production, isolation, drug loading efficiency, and biodistribution and uptake. Journal of Controlled Release. 2022. 347:533-543.
For Research Use Only. Cannot be used by patients.
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