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Magic™ Antibody Discovery - Human DR6 / TNFRSF21 (42-350) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP1372F)

Datasheet
This membrane protein is Human DR6 / TNFRSF21 (42-350). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DR6 / TNFRSF21
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 60.2 kDa. The protein migrates as 80-95kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 42 - Leu 350 (Accession # AAH17730).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • DR6 / TNFRSF21
  • Full Name
  • TNF receptor superfamily member 21
  • Introduction
  • This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.
  • Alternative Names
  • DR6; CD358; BM-018; tumor necrosis factor receptor superfamily member 21; TNFR-related death receptor 6; death receptor 6

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