Magic™ Membrane Protein Human LILRB4 (Leukocyte immunoglobulin like receptor B4) Expressed in NS0 for Antibody Discovery, Partial (17-257aa) (CAT#: MPX0480K)

Datasheet

This product is a 27 kDa Human LILRB4 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
LILRB4

Protein Length
Partial (17-257aa)

Protein Class
Receptor; Immunity

Molecular Weight
27 kDa

Sequence
PRTHMQAGPLPKPTLWAEPGSVISWGNSVTIWCQ
GTLEAREYRLDKEESPAPWDRQNPLEPKNKARFSIPSMTEDYAGRYRCYY
RSPVGWSQPSDPLELVMTGAYSKPTLSALPSPLVTSGKSVTLLCQSRSPM
DTFLLIKERAAHPLLHLRSEHGAQQHQAEFPMSPVTSVHGGTYRCFSSHG
FSHYLLSHPSDPLELIVSGSLEDPRPSPTRSVSTAAGPEDQPLMPTGSVP
HSGLRRH

Product Description

Activity
Yes

Expression Systems
NS0

Tag
6xHis tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 100 μg/mL in PBS.

Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
LILRB4

Full Name
Leukocyte immunoglobulin like receptor B4

Introduction
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative Names
LILRB4; ILT3; LIR5; CD85K; ILT-3; LIR-5; leukocyte immunoglobulin-like receptor subfamily B member 4; CD85 antigen-like family member K; immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; leukocyte immunoglobulin-like receptor 5; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; monocyte inhibitory receptor HM18; Leukocyte immunoglobulin like receptor B4

Gene ID
11006

UniProt ID
Q8NHJ6

Customer reviews and Q&As Write a review Ask a question

Related Products

Online Inquiry

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: