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Magic™ Membrane Protein Mouse HTR1A (5-hydroxytryptamine (serotonin) receptor 1A) (CAT#: MP0018F)

Datasheet
The 5-HT1A (5-HydroxyTryptamine Receptor 1A) receptor is a subtype of serotonin (5- hydroxytryptamin) receptor located in presynaptic and postsynaptic regions. This receptor plays a role in the regulation of dopamine and serotonin levels in the brain, and thereby affects neural activity, mood and behavior. The 5-HT1A receptors are G-protein coupled receptors that exert their effects through Gi/o proteins to inhibit adenylyl cyclase, as well as other second messenger cascades such as MAPK pathway. The activation of this receptor has been involved in the mechanism of action of anxiolytic, antidepressant and antipsychotic medications.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • HTR1A
  • Protein Length
  • Full Length
  • Protein Class
  • GPCR class A
  • Molecular Weight
  • 46.1 kDa
  • TMD
  • 7
  • Sequence
  • MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAA
    IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
    TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
    RSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGT
    SFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGN
    SKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLP
    FFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
    R

Product Description

  • Activity
  • To be tested
  • Application
  • Screening & display technologies, Antibody development, Structural Biology
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >50% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • HTR1A
  • Full Name
  • 5-hydroxytryptamine (serotonin) receptor 1A
  • Introduction
  • This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response.
  • Alternative Names
  • Gpcr18, 5HT1A

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