Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs has accumulated extensive experience in providing custom scaffold development services. With our cutting-edge proprietary technologies, now we can obtain the target-specific intracellular proteins based on the novel NanoScaffold, CpNS. We are pleased to use our proprietary Hi-Affi™ platform to generate the CpNS libraries with 100% precise mutation and over 1010 diversity.
With the properties of flexible size, versatile functions, and complex structure, proteins can always recognize and modulate disease-related macromolecules, so that they present great potential as small-molecule reagents. However, most proteins cannot cross the lipid bilayer membrane of mammalian cells, which largely limit the biological therapeutic and diagnostic against intracellular targets. Some studies have shown that cationic resurfacing of proteins can endow cell penetration. The magnitude of the net theoretical charge may influence the characterizations of proteins, which include aggregation, stability, solubility, and also the ability to penetrate the target cells. The problem is many proteins are not amenable to such extensive mutagenesis. Now Creative Biolabs can generate a novel NanoScaffold, known as CpNS, to obtain the cell-penetrating binders against intracellular targets.
The CpNS is composed of a modified framework region with an exposed polycationic surface and three loops available for mutation. According to a variety of modifications, we have got several stable framework available for CpNS design. Based on our advanced nucleotide doping techniques (NNK/NNS, and Trimer Codon strategy), the CpNS library can be constructed through properly design and well control. After a series of screening strategies, the desired cell-penetrating binders can be obtained. In addition, the antigen binding region of existing ligand has a potential possibility to integrated with CpNS scaffold to generate new binders with cell-penetrating ability. It is worth mentioning that reporter proteins can also be fused to CpNS for biological purposes and functions.
Creative Biolabs is one of the well-recognized experts who are professional in applying advanced phage display technologies for a broad range of scaffold protein research. Based on our extensive experience and advanced platforms, we are confident in filling the gaps in the scaffold field. If you are interested in our Fynomers library construction service, please do not hesitate to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
