Repeat Protein Design

A central question in protein design is the extent to which naturally existing proteins sample the space of folded structures accessible to the polypeptide chain. Repeat proteins composed by multiple tandem copies of a modular unit are universal in nature and play key roles in biomolecular recognition, signal transduction, and other critical biological processes. As a first-class provider in the protein design services, Creative Biolabs offers advanced engineering services and multiple computational protein design methods for functional repeat proteins which have been modified for molecular recognition and modular scaffolding applications.

Repeat Proteins

Repeat Protein Design

Repeat proteins are essential for various biological programs ranging from cell adhesion to signaling to defense mechanisms. These proteins consist of proximal suites of usually different repeated amino acid sequences. In most cases, the repeated units cooperatively fold into either a toroid-shaped or a solenoid-shaped structure. Despite extremely diverse in sequence and structure, repeat proteins are characterized by short-ranged intra-repeat and inter-repeat interactions between residues neighbor in sequence. The inherent modularity of repeat proteins allows the combination of functionalities in a single domain, such as recognition motifs for peptides and nucleic acids, and can be exploited to generate biomaterials with tunable mechanical properties.

Rational Protein Design Services at Creative Biolabs

Proteins that carry patterns of repetitive sequences largely fold with well-defined motifs and thus can better message the sequence-structure information than most proteins. They mainly work as protein-protein interactors with binding interfaces that aren't conserved along with other family members but specific for each interacting pair. The repeat proteins have been widely used as scaffolds for protein design that are generally centered on the maximization of the stability of repeat arrays. At Creative Biolabs, we're dedicated to the state-of-the-art ideas of repeat protein design and has established the following methods for desired synthetic binding proteins.

Protein design strategies using repeat proteins as scaffolds have made impressive advances with hundreds of already on-going applications. Computational protein design has realized the goal of finding an energy-optimal amino acid sequence for a backbone structure. As a well-known partner in the biopharmaceutical field, Creative Biolabs has built a series of protein engineering services for repeat protein design. These designed molecules are well behaved to favor expression and folding that can perform further optimization of binding a specific target. If you’re interested in our techniques, please don’t hesitate to contact usor send us an inquiry.


  1. Parmeggiani, F.; et al. Designing repeat proteins: a modular approach to protein design. Curr Opin Struct Biol. 2017, 45: 116-123.
  2. Parmeggiani, F.; et al. A general computational approach for repeat protein design. J Mol Biol. 2015, 427(2): 563-575.
  3. Brunette, T.J.; et al. Exploring the repeat protein universe through computational protein design. Nature. 2015, 528(7583): 580-584.

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