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Bispecific Single Domain Antibody Production

Scientists in Creative Biolabs are pleased to introduce our bispecific single domain antibody service, which combined our unparalleled expertise in both single domain antibody and bispecific antibody field. Much like validated recombinant antibody formats such as tandem scFv and BiTE (Bispecific T Cell Engager), single domain antibody against the same as well as different targets can be designed and engineered into bivalent and bispecific formats with excellent bioactivity and stability.

Bispecific Single Domain Antibody Production
Bispecific Single Domain Antibodies (<Bispecific Antibodies>, Springer 2011)

Bispecific antibodies (bsAbs), which are capable of simultaneous binding to two different targets, are considered the most promising solution to increase therapeutic activity by retargeting a large variety of payloads to cancer cells. However, the potential application of those antibody formats has been significantly limited due to the difficulty in producing large amounts of homogenous preparations of bispecific antibodies; none of them have met so far all the requirements to become a standard format for clinical applications. Being the smallest fully functional antibody fragments, single domain antibodies have many outstanding physical properties such as high production yields and good stability, and may accelerate the way toward this goal.

With over 10 years of experience in antibody engineering field, Creative Biolabs has been a recognized leader in the field of single domain antibody production and single domain antibody library. We have tried various approaches to create bispecific antibodies using single domain antibody , among which a commonly used strategy is to link two single domain antibodies via a peptidic linker, thereby creating a tandem single domain antibody. We have successfully produced a few bispecific single domain antibodies with neutralization activity obtained using a specially designed linker based on the hinge region of the llama IgG2a isotype. As these single domain antibodies are small, very efficiently produced and highly stable, they represent ideal building tools to create more elaborate molecules especially bispecific antibodies.

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