Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsWith the most advanced technology and years of experience in the antibody engineering field, Creative Biolabs now provides custom construction and production services for tandem scFv. Tandem scFvs are recombinant fusion proteins consisting of two single-chain variable fragments. The two scFvs can bind two receptors or ligands simultaneously or retarget immune cells, such as T cells and NK cells, to disease tissues. The latter format is also named bispecific immune cell engagers, such as bispecific T cell engagers and bispecific NK cell engagers, and have been widely studied in tumor immunotherapy. One of the scFvs binds to immune cells via their markers, such as CD3 of T cells, and the other to tumor cells via tumor-associated antigen (TAA).
Our scientists are fully aware that the construction of tandem scFv is far more complicated than linking just two scFv fragments together. There are details need to be taken into consideration when designing the molecule, which may greatly affect the stability, specificity, and homogeneity. The orientation of VH and VL as well as the linkers (between the two scFvs or inside each scFv) may greatly affect the stability, expression level, and binding ability. In some cases, only one of these forms can produce functional molecules. Therefore, it is suggested that pre-experiment is necessary by changing the orientation of VH-VL, expressing in small scale and testing the activity before scale-up production.
Tandem scFv therapeutics are currently being evaluated in different clinical indications. Several tandem scFv programs have entered the clinic and published results from these programs show evidence of clinical remissions. Based on the investigations on dozens of bispecific molecules in pre-clinical and clinical trials, scientists from Creative Biolabs are pleased to work on your project for the discovery of new bispecific antibodies for cancer therapy.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
