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Anti-Membrane Protein Antibody Discovery via Native™ Platform

Empowered by experienced scientific teams and cutting-edge technologies in membrane protein as well as antibody discovery, Creative Biolabs now proudly introduces to our global clients our professional anti-membrane protein antibody discovery service via our unique Native™ antibody discovery platform.

Membrane proteins act as one critical class of medical targets against various disease types. Nowadays, antibodies targeting membrane proteins have become attracting increasing research interest, due to the high specificity, high affinity, low cytotoxicity and versatile functions. However, it can be quite challenging to raise ideal binders against membrane proteins. For one, membrane proteins are generally large molecules with multiple domains, which is very difficult to isolate and purify; besides, binders shall be able to elicit proper cellular functionalities. Therefore, a prerequisite is to have large pool of binders first. Traditional hybridoma is restricted by limited cell fusion efficiency that can lead to loss of many promising candidates. Phage display, on the other hand, is able to create a massive library with large capacity, but the library members have lost original VH-VL pairs, which can be problematic in downstream development. To face these challenges, Creative Biolabs has established an innovative Native™ Platform. Based on antigen-specific B lymphocytes cytometry technology, we can analyze and isolate every single cell that can interact with the specific target from the whole B cell repertoire. Anti-membrane protein antibody development using Native™ platform can offer many unique features including:


Anti-Membrane Protein Antibody Discovery via Native™ Platform

There are following host species available in Creative Biolabs. If none of the species meets your need, you are welcome to contact us, and our diligent scientists will be glad to work out a proper solution for you.


In addition, Creative Biolabs is also specialized in tailoring high-quality membrane protein antigens and immunization plan. Our one-stop membrane protein immunogen preparation service can help you to obtain various GPCR immunogens, ion channel immunogens and transporter immunogens in form of liposome, detergent, nanodisc, etc. We also offer versatile immunization strategies for your selection. Please feel free to contact us for more details.

Reference

  1. Kodituwakku A P, Jessup C, Zola H, et al. (2003). Isolation of antigen-specific B cells. Immunology and Cell Biology. 81(3), 163-70.



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