ADC Linker Products

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Product Overview

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

ADC Linker Services

Creative Biolabs offers a comprehensive "DrugLnk" linker module designed to cater to the diverse needs of antibody-drug conjugate (ADC) development. This module focuses on the design and preparation of various types of linkers, tailored to their specific drug release mechanisms. Clients can choose from a range of linker types:

Leveraging an advanced synthetic chemistry platform along with an extensive inventory of toxins, linkers, and drug-linker sets, "DrugLnk" at Creative Biolabs enables our skilled chemists to provide specialized services.

(1) Design linkers with optimal size
(2) Select linkers with suitable release mechanism
(3) Engineer linkers with compatible conjugation chemistry
(4) Synthesize customized linkers
(5) Modify payload drug
(6) Design synthesis routes
(7) Synthesize customized drug-linker complexes

Please feel free to contact us for more information about our ADC linker services.

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

Global Antibody-drug Conjugate (ADC) Clinical Trial ReviewGlobal Antibody-drug Conjugate (ADC) Clinical Trial Review 2018.3

Creative Biolabs ADC Product Brochure

Protocol

Quick Links

ADC Toxins

Drug-linker Complexes

Customized ADCs

Anti-Ab ADCs

Product List

Catalog	Product name	CAS NO	Structure	Molecular Weight	Purity	Data sheet	Inquiry
ADC-L-Y0529	17-(Bromoacetamido-PEG9-ethylcarbamoyl)nonanoic t-butyl ester			817.9	95%		Inquiry
ADC-L-Y0530	17-(Bromoacetamido-PEG9-ethylcarbamoyl)tridecanoic t-butyl ester			874	95%		Inquiry
ADC-L-Y0531	17-(Bromoacetamido-PEG9-ethylcarbamoyl)heptadecanoic t-butyl ester			930.1	95%		Inquiry
ADC-L-Y0532	Bis-Bromoacetamido-PEG11	951308-86-4		786.6	95%		Inquiry
ADC-L-Y0535	5-(tetrahydro-2H-pyran-2-yloxy)pent-3-yn-1-PEG4-bromide			423.3	95%		Inquiry
ADC-L-M0002	Methylamino-PEG2-acid	1807503-87-2		191.2	95%		Inquiry
ADC-L-M0003	Methylamino-PEG4-acid	1283658-71-8		279.3	95%		Inquiry
ADC-L-M0005	Methylamino-PEG2-t-butyl ester	1807521-04-5		247.3	95%		Inquiry
ADC-L-M0006	Methylamino-PEG4-t-butyl ester	1621616-14-5		335.4	95%		Inquiry
ADC-L-M0007	N-Me-N-bis(PEG4-t-butyl ester)				95%		Inquiry
ADC-L-M0009	Methylamino-PEG5-azide	2055046-24-5		320.4	95%		Inquiry
ADC-L-M0011	Hydroxy-PEG2-methylamine	282551-10-4		163.2	95%		Inquiry
ADC-L-M0012	Hydroxy-PEG3-methylamine	90430-59-4		207.3	95%		Inquiry
ADC-L-M0014	Tetraethyl butane-1,4-diylbis(phosphonate)	7203-67-0		330.3	95%		Inquiry
ADC-L-M0015	Tetraethyl heptane-1,7-diylbis(phosphonate)	5943-17-9		372.4	95%		Inquiry
ADC-L-M0016	Tetraethyl octane-1,8-diylbis(phosphonate)	5943-61-3		386.4	95%		Inquiry
ADC-L-M0017	Tetraethyl decane-1,10-diylbis(phosphonate)	5943-62-4		414.5	95%		Inquiry
ADC-L-M0018	Butane-1,4-diyldiphosphonic acid	4671-77-6		218.1	95%		Inquiry
ADC-L-M0019	Hexane-1,6-diyldiphosphonic acid	4721-22-6		246.1	95%		Inquiry
ADC-L-M0020	[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid	1446282-24-1		358.4	95%		Inquiry