ADC Linker Products

Product Overview Related Services Scientific Resources Quick Links Product List

Product Overview

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

ADC Linker Services

Creative Biolabs offers a comprehensive "DrugLnk" linker module designed to cater to the diverse needs of antibody-drug conjugate (ADC) development. This module focuses on the design and preparation of various types of linkers, tailored to their specific drug release mechanisms. Clients can choose from a range of linker types:

Leveraging an advanced synthetic chemistry platform along with an extensive inventory of toxins, linkers, and drug-linker sets, "DrugLnk" at Creative Biolabs enables our skilled chemists to provide specialized services.

(1) Design linkers with optimal size
(2) Select linkers with suitable release mechanism
(3) Engineer linkers with compatible conjugation chemistry
(4) Synthesize customized linkers
(5) Modify payload drug
(6) Design synthesis routes
(7) Synthesize customized drug-linker complexes

Please feel free to contact us for more information about our ADC linker services.

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

Global Antibody-drug Conjugate (ADC) Clinical Trial ReviewGlobal Antibody-drug Conjugate (ADC) Clinical Trial Review 2018.3

Creative Biolabs ADC Product Brochure

Protocol

Quick Links

ADC Toxins

Drug-linker Complexes

Customized ADCs

Anti-Ab ADCs

Product List

Catalog	Product name	CAS NO	Structure	Molecular Weight	Purity	Data sheet	Inquiry
ADC-L-M0021	4-bromobutylphosphonic acid	1190-14-3		217	95%		Inquiry
ADC-L-M0022	6-Bromohexylphosphonic acid	133345-66-1		245.1	95%		Inquiry
ADC-L-M0023	10-bromodecylphosphonic acid	934985-98-5		301.2	95%		Inquiry
ADC-L-M0024	diethyl 4-bromobutylphosphonate	63075-66-1		273.1	95%		Inquiry
ADC-L-M0025	diethyl 7-bromoheptylphosphonate	100462-73-5		315.2	95%		Inquiry
ADC-L-M0026	diethyl 8-bromooctylphosphonate	124939-70-4		329.2	95%		Inquiry
ADC-L-M0027	diethyl 10-bromodecylphosphonate	272785-01-0		357.3	95%		Inquiry
ADC-L-M0028	diethyl 12-bromodecylphosphonate	264231-28-9		385.3	95%		Inquiry
ADC-L-M0029	Alkynyl Myristic Acid	82909-47-5		224.3	95%		Inquiry
ADC-L-M0030	Alkynyl Palmitic Acid	99208-90-9		252.4	95%		Inquiry
ADC-L-M0031	Alkynyl Stearic Acid	34450-18-5		280.5	95%		Inquiry
ADC-L-M0032	1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE	117499-16-8		303.4	95%		Inquiry
ADC-L-M0033	{2-[(4-{[Bis-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-benzyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester	1807521-06-7		708.9	95%		Inquiry
ADC-L-M0034	Benzenedimethanamine-diethylamine	71277-17-3		308.5	95%		Inquiry
ADC-L-M0038	SMPH Crosslinker	367927-39-7		379.4	95%		Inquiry
ADC-L-M0039	SPDP acid	68617-64-1		215.3	95%		Inquiry
ADC-L-M0040	SPDP NHS ester	68181-17-9		312.4	95%		Inquiry
ADC-L-M0042	SPDP-C6-Sulfo-NHS ester	169751-10-4		527.6	95%		Inquiry
ADC-L-M0043	ANB-NOS Crosslinker	60117-35-3		305.2	95%		Inquiry
ADC-L-M0044	Fmoc-NH-pentoic acid-NHS-SO3Na				95%		Inquiry