Human AFP Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-AFP, IgG2a KappaDetection Antibody: Rabbit purified polyclonal anti-AFP
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Antigen Detail | |
|---|---|
| Target | AFP |
| Description | Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01986 |
| Isotype | IgG2a, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human AFP Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-AFP, IgG2a Kappa Detection Antibody: Rabbit purified polyclonal anti-AFP |
| Specificity | Validated for detecting natural and recombinant human AFP |
| Research Area | Plasma protein |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | AFP |
| Full Name | Alpha Fetoprotein |
| Background | This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Oct 2019] |
| Alternative Names | Alpha-1-Fetoprotein; HPAFP; FETA; AFPD |
| Gene ID | 174 |
| Uniprot ID | P02771 |
| GeneCards | AFP |
| HGNC | 317 |
| Ensembl | ENSG00000081051 |
| OMIM | 104150 |
| Involvement in Disease | Diseases associated with AFP include Alpha-Fetoprotein Deficiency and Alpha-Fetoprotein, Hereditary Persistence Of. |
| Function | The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. |
| Related Pathways | Its related pathways are FOXA2 and FOXA3 transcription factor networks and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. |
For Research Use Only.
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