Tissue level detection is an important part of in vitro diagnostics (IVD). With extensive experience and mature technologies, Creative Biolabs is capable of providing high-quality and comprehensive tissue-level detection services to global researchers.

Phospho Histone-H3 immunohistochemistry.Fig.1 Phospho Histone-H3 immunohistochemistry. (Erickson, 2018)

Immunohistochemistry Analysis

Immunohistochemistry (IHC) is a powerful technique that has revolutionized histopathological diagnosis in the past several decades. IHC employs antibodies to identify cellular components. Using IHC is possible to diagnose tumors by detecting the presence of tissue-specific antigens that are only expressed in certain types of cells. For example, the pathologist can be reasonably confident that a poorly differentiated neoplasm is carcinoma and not a melanoma or high-grade lymphoma if its constituent cells are immunoreactive for epithelial cell-specific markers such as cytokeratins, and in turn, do not stain for antigens expressed solely by lymphocytes or melanoma cells.

Digital Pathology Analysis

Digital pathology and whole slide imaging (WSI) - the complete digitization of slides - has the potential to transform the practice of diagnostic pathology. Digital pathology encompasses all the associated technologies that leverage digital slides to allow improvements and innovations in the workflow. WSI refers only to the high-resolution digitization and storage of entire glass pathology slides as digital slides. Image analysis is beginning to generate useful diagnostic data from H&E stained slides by analyzing metrics such as lymphocyte density, tumor stroma composition, and nuclear morphometry and textural analysis. These approaches have been used in breast, colorectal, and ovarian cancer case series.

Digital pathology in medicine.Fig.2 Digital pathology in medicine. (Madabhushi, 2016)

Services at Creative Biolabs

Committed to the IVD development services for years, Creative Biolabs has a comprehensive technology platform with advanced facilities. With years of experience accumulated from practice, our mature technologies give us confidence in providing customer-satisfied tissue-level detection services.

  • Rich experience and extensive expertise
  • Mature technologies and mature technicians
  • Preferential price

As a global-leading biotechnology company, Creative Biolabs has strong foundations and excellent scientific staff as the powerful guarantee of our services. If you are interested in tissue level IVD detection services or any other IVD development services, please don't hesitate to contact us for more information.


  1. Madabhushi, A.; Lee, G. Image analysis and machine learning in digital pathology: Challenges and opportunities. Med Image Anal. 2016, 33: 170-175.
  2. Erickson, L. A.; Mete, O. Immunohistochemistry in diagnostic parathyroid pathology. Endocr Pathol. 2018, 29(2): 113-129.

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