Today’s situation in in vitro diagnostics requires accurate and rapid analysis. Electrochemical biosensor combines the sensitivity of electroanalytical methods with the inherent bio-selectivity of the biological component. As a trusted biosensor research company, Creative Biolabs offers precise design, processing and extensive electrochemical biosensor development services. We are your committed partner in combining electrochemical biosensor development with biomolecules detection.
The electrochemical biosensor is one of the typical sensing devices based on transducing the biochemical events to electrical signals. Flexible electrochemical biosensors play an important role in disease diagnosis. They have various advantages over existing biosensors, such as miniaturization, real-time monitoring, and the enhancement of selectivity and sensitivity. Based on the nature of the biological modification, electrochemical biosensors can be classified as either affinity or biocatalytic sensors. Affinity sensors have a binding recognition element that releases a signal when it is coupled to the target such as antibodies. Biocatalytic sensors are modified with biological elements able to recognize a target and induce a response of an electroactive molecule such as enzymes.
Fig.1 Scheme of analytical principle for electrochemical biosensors. (Cho, 2020)
Electrochemical methods used in detection field can be classified as potentiometric, amperometric, conductometric, impedimetric, and ion-charge / field-effect. One of the main uses is to directly monitor analytes or the biological activity related to the analyte production or consumption. To date, electrochemical biosensors have enabled sample preparation-free detection of pathogens in various matrices, in situ detection of pathogens on surfaces, rapid pathogen detection using low-cost platforms, multiplexed detection of pathogens in practical matrices, and detection of pathogens via wireless actuation and data acquisition formats. Besides, numerous electrochemical biosensors have been developed and proposed for detection of various diseases such as infectious disease, genetic diseases and cancers based on specific biomarkers.
Fig.2 Schematic illustration of electrochemical impedimetric biosensor for the detection of PfHRP-II. (Dutta, 2020)
Creative Biolabs specializes in the design of electrochemical sensors, including Ion Selective Electrodes (ISE), utilizing precision printing or ablated circuitry coupled with the precise deposition of a reagent to impart specificity based on voltametric, potentiometric and conductometric parameters. We are committed to transforming the theoretical advantages of electrochemical biosensors into reality in the field of diagnosis. Our featured services include but not limited to the following:
Serving a wide variety of industries, our team of scientists and engineers quickly transform electrochemical sensor concepts into viable prototypes. As a uniquely biosensor and IVD research company, Creative Biolabs follows up with scalable manufacturing to deliver finished products that are reliable, easy-to-use and highly cost-effective. If you are interested in our electrochemical biosensor development or detection services, please feel free to contact us for more information.
References
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