Microfluidics

With the unique features of miniaturization, high integration, and low cost, Microfluidics is emerging as a powerful tool for disease diagnosis and monitor. Creative Biolabs offers unique and adaptable Microfluidic-based detection and analysis services for in vitro diagnostics (IVD) of different diseases. Armed with the advancement of the cloud, digital medicine, and nanotechnology, the integration of new emerging elements would bring advances to assay sensitivity, stability, and robustness.

Technology Introduction

Microfluidics, or lab-on-a-chip technology, is a powerful tool that sits at the intersection of biotechnology, automation, and functional integration. By using different fabrication techniques to make fluid flow cells, Microfluidic devices can shuttle picoliter, volumes of fluids into functional regions, enabling powerful IVD harnessing everything from digital biology, next generation sequencing, organs-on-a-chip, high-throughput cell-based assays, or high-density multifunctional chips for drug discovery and bioanalysis for shrinking sample and reagent volumes.

Application of Microfluidics in IVD

Early detection of diseases such as HIV/AIDS, cancer, and chronic respiratory diseases has the potential to reduce mortality rates, and portable, easy-to-use, and affordable diagnostic methods/products provide an optimal platform for disease recognition. The majority of Microfluidic products that have been recently developed work by sensing specific biomarkers, human cell types, bacteria, or viruses. Four high-impact applications for Microfluidic diagnostic research include infectious diseases, autoimmune diseases, cancer, and cardiovascular diseases.

Fig.1 Microfluidic technology for biomarker, human cell, bacteria, and virus detection.^{1, 2}

Microfluidic approaches have also been well suited to investigate single cell behavior due to their increased sensitivity, economy of scale and ease of automation. This technique plays a critical role in delineating heterogenetic cellular sub-populations by providing phenotypic-genotypic correlations, eventually contributing to an effective understanding of personalized nature of the disease.

Incomparable Advantages Over Conventional Detection Techniques

• Microfluidics allows for highly sensitive and controllable conditions by facilitating the predictable passage of fluids through microchannels due to laminar flow.
• Manipulated sensitivity to provide researchers with ways to produce detection and single cell analysis methods that cannot be recreated on a larger scale.
• Microfluidics provides integrated approaches for the individual analyte or multiplexed protein and nucleic acid analysis.

Our Featured Services

At Creative Biolabs, Microfluidic technology makes full use of advantages in the field of disease detection and their use in diagnostic understanding. Creative Biolabs now provides the following services based on Microfluidic technology. Please refer to corresponding page for details.

Nucleic Acid Detection Services based on Microfluidics

Protein Detection Services based on Microfluidics

Integrated Approach for Multiplexed Protein and DNA Analysis

Single Cell Analysis based on Microfluidics

Microfluidic Technology and Infectious Diseases Diagnosis

Microfluidic Technology and Cancer Diagnosis

Internet of Things based Microfluidic System Development Services

Microfluidic-based POCT Development Services

If you are interested in our services, please feel free to contact us for more information.

References

1. Campbell, Joshua M., et al. "Microfluidic and paper-based devices for disease detection and diagnostic research." International journal of molecular sciences 19.9 (2018): 2731.
2. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only.