Human DCXR Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-DCXRDetection Antibody: Mouse polyclonal anti-DCXR
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Antigen Detail | |
|---|---|
| Target | DCXR |
| Description | Dicarbonyl/L-xylulose reductase, also known as carbonyl reductase II, is an enzyme that in human is encoded by the DCXR gene located on chromosome 17. The insufficiency of L-xylulose reductase activity causes an inborn error of metabolism disease characterized by excessive urinary excretion of L-xylulose. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human DCXR Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-DCXR Detection Antibody: Mouse polyclonal anti-DCXR |
| Specificity | Validated for detecting natural and recombinant human DCXR |
| Research Area | Metabolism |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DCXR |
| Full Name | Dicarbonyl And L-Xylulose Reductase |
| Background | The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene. |
| Alternative Names | HCRII; PNTSU; KiDCR |
| Gene ID | 51181 |
| Uniprot ID | Q7Z4W1 |
| HGNC | 18985 |
| Ensembl | ENSG00000169738 |
| OMIM | 608347 |
| Involvement in Disease | Diseases associated with DCXR include Pentosuria and Acute Inflammation Of Lacrimal Passage. |
| Function | Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. |
| Related Pathways | Its related pathways are Porphyrin and chlorophyll metabolism and Metabolism. |
For Research Use Only.
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