Human DNAI1 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-DNAI1Detection Antibody: Mouse polyclonal anti-DNAI1
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Antigen Detail | |
|---|---|
| Target | DNAI1 |
| Description | Dynein intermediate chain 1, axonemal is a protein that in humans is encoded by the DNAI1 gene. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human DNAI1 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-DNAI1 Detection Antibody: Mouse polyclonal anti-DNAI1 |
| Specificity | Validated for detecting natural and recombinant human DNAI1 |
| Research Area | Neurology process |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DNAI1 |
| Full Name | Dynein Axonemal Intermediate Chain 1 |
| Background | This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. |
| Alternative Names | ICS1; PCD; DIC1 |
| Gene ID | 27019 |
| Uniprot ID | Q9UI46 |
| GeneCards | DNAI1 |
| HGNC | 2954 |
| Ensembl | ENSG00000122735 |
| OMIM | 604366 |
| Involvement in Disease | Diseases associated with DNAI1 include Ciliary Dyskinesia, Primary, 1 and Kartagener Syndrome. |
| Function | Part of the dynein complex of respiratory cilia. |
| Related Pathways | Its related pathways are Parkinson disease. |
For Research Use Only.
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