Human DNAJB2 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-DNAJB2Detection Antibody: Mouse monoclonal anti-DNAJB2, IgG1 Kappa
Specific Inquiry(Note: Please select the requirements to fit you project. If you have any other requirements, please specify. If no specific requirements, you don't need to select any button.)
Antigen Detail | |
|---|---|
| Target | DNAJB2 |
| Description | DnaJ homolog subfamily B member 2 is a protein that in humans is encoded by the DNAJB2 gene. The DNAJB2 gene is associated with autosomal recessive distal hereditary motor neuropathy, also known as distal spinal muscular atrophy 5 (DSMA5) (MedGen UID: 766903) and Charcot-Marie-Tooth disease type 2T (CMT2T) (MedGen UID: 911048). |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD10494 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human DNAJB2 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-DNAJB2 Detection Antibody: Mouse monoclonal anti-DNAJB2, IgG1 Kappa |
| Specificity | Validated for detecting natural and recombinant human DNAJB2 |
| Research Area | Protein folding |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DNAJB2 |
| Full Name | DnaJ Heat Shock Protein Family (Hsp40) Member B2 |
| Background | This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Alternative Names | CMT2T; HSJ1 |
| Gene ID | 3300 |
| Uniprot ID | P25686 |
| GeneCards | DNAJB2 |
| HGNC | 5228 |
| Ensembl | ENSG00000135924 |
| OMIM | 604139 |
| Involvement in Disease | Diseases associated with DNAJB2 include Spinal Muscular Atrophy, Distal, Autosomal Recessive, 5 and Dnajb2-Related Charcot-Marie-Tooth Disease Type 2. |
| Function | Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). |
| Related Pathways | Its related pathways are Protein processing in endoplasmic reticulum. |
For Research Use Only.
Related products Application
