Human DNALI1 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-DNALI1Detection Antibody: Mouse polyclonal anti-DNALI1
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Antigen Detail | |
|---|---|
| Target | DNALI1 |
| Description | Dynein Axonemal Light Chain 4 (DNAL4) protein is understood to be part of the axonemal (or ciliary and flagellar) complex of dynein molecules (including dynein heavy and light chains) (GO:0005858) and a component of the microtubule-based dynein motor complex.In humans, two known axonemal light chain proteins, DNAL1 and DNAL4, sit at the outer edge of the complex. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human DNALI1 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-DNALI1 Detection Antibody: Mouse polyclonal anti-DNALI1 |
| Specificity | Validated for detecting natural and recombinant human DNALI1 |
| Research Area | Cytoskeleton |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DNALI1 |
| Full Name | Dynein Axonemal Light Intermediate Chain 1 |
| Background | This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. |
| Alternative Names | Dynein; Axonemal; Light Intermediate Polypeptide 1 |
| Gene ID | 7802 |
| Uniprot ID | O14645 |
| HGNC | 14353 |
| Ensembl | ENSG00000163879 |
| OMIM | 602135 |
| Involvement in Disease | Diseases associated with DNALI1 include Osteogenesis Imperfecta, Type Xi and Primary Ciliary Dyskinesia. |
| Function | May play a dynamic role in flagellar motility. |
| Related Pathways | Its related pathways are Parkinson disease. |
For Research Use Only.
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