Human DNMBP Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-DNMBPDetection Antibody: Rabbit purified polyclonal anti-DNMBP
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Antigen Detail | |
|---|---|
| Target | DNMBP |
| Description | DNMBP loss-of-function variants cause infantile-onset cataracts in humans. The rs3740058 in DNMBP was significantly differently in genotype between Alaheimer diease and control in APOE epsilon4epsilon4 subgroup, but showed no effect on Alzheimer disease risk, either did rs11190305 polymorphisms in DNMBP. DNMBP belongs to the DBL (MIM 311030) family of guanine nucleotide exchange factors and plays a role in the regulation of cell junctions (Otani et al., 2006 [PubMed 17015620]). |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01929 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human DNMBP Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-DNMBP Detection Antibody: Rabbit purified polyclonal anti-DNMBP |
| Specificity | Validated for detecting natural and recombinant human DNMBP |
| Research Area | Cell junctions |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DNMBP |
| Full Name | Dynamin Binding Protein |
| Background | This gene encodes a protein belonging to the guanine nucleotide exchange factor family, and which regulates the configuration of cell junctions. It contains multiple binding sites for dynamin and thus links dynamin to actin regulatory proteins. Polymorphisms in this gene have been linked to Alzheimer's disease in some populations, though there are conflicting reports of such linkages in other populations. Alternative splicing results in multiple transcript variants. |
| Alternative Names | ARHGEF36; Scaffold Protein TUBA |
| Gene ID | 23268 |
| Uniprot ID | Q6XZF7 |
| HGNC | 30373 |
| Ensembl | ENSG00000107554 |
| OMIM | 611282 |
| Involvement in Disease | Diseases associated with DNMBP include Cataract 48 and Cataract 44. |
| Function | lays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). |
| Related Pathways | Its related pathways are Regulation of CDC42 activity. |
For Research Use Only.
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