Human DPP2 antibody pair set for ELISA useCapture Antibody: Mouse anti-DPPⅡ monoclonal antibodyDetection Antibody: Mouse anti-DPPⅡ monoclonal antibody conjugated to HRP
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Antigen Detail | |
|---|---|
| Target | DPP2 |
| Description | DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01491 |
| Purification | Affinity Chromatography |
| Buffer | Prior to lyophilization: CBS |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | HRP |
| Clone | RD10364 |
| Purification | Affinity Chromatography |
| Buffer | Prior to lyophilization: 0.5% BSA in wash buffer, pH 7.2 - 7.4, 0.2 μm filtered |
General Product Property | |
|---|---|
| Product Overview | Human DPP2 antibody pair set for ELISA use Capture Antibody: Mouse anti-DPPⅡ monoclonal antibody Detection Antibody: Mouse anti-DPPⅡ monoclonal antibody conjugated to HRP |
| Specificity | Quantitative determination of Human DPP2 |
| Range | 62.5-4000 pg/mL |
| Research Area | Proteolysis |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DPP7 |
| Full Name | Dipeptidyl Peptidase 7 |
| Background | The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. |
| Alternative Names | DPP2 |
| Gene ID | 29952 |
| Uniprot ID | Q9UHL4 |
For Research Use Only.
Application
