Human DSC2 Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-DSC2Detection Antibody: Rabbit purified polyclonal anti-DSC2
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Antigen Detail | |
|---|---|
| Target | DSC2 |
| Description | Dsc2 protein is predominantly localized to specialized adhesion junctions between the cortex and the medulla. DSC3 is expressed in all living epidermal layers as well as in glandular ducts, basal matrix cells and the outer root sheath of hair follicles. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01552 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human DSC2 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-DSC2 Detection Antibody: Rabbit purified polyclonal anti-DSC2 |
| Specificity | Validated for detecting natural and recombinant human DSC2 |
| Research Area | Cytoskeleton |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DSC2 |
| Full Name | Desmocollin 2 |
| Background | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. |
| Alternative Names | Cadherin Family Member 2; ARVD11; DSC2 |
| Gene ID | 1824 |
| Uniprot ID | Q02487 |
| GeneCards | DSC2 |
| HGNC | 3036 |
| Ensembl | ENSG00000134755 |
| OMIM | 125645 |
| Involvement in Disease | Diseases associated with DSC2 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 11 and Familial Isolated Arrhythmogenic Ventricular Dysplasia, Right Dominant Form. |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
| Related Pathways | Its related pathways are Keratinization and Arrhythmogenic right ventricular cardiomyopathy (ARVC). |
For Research Use Only.
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