Human EDA2R Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-EDA2RDetection Antibody: Mouse polyclonal anti-EDA2R
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Antigen Detail | |
|---|---|
| Target | EDA2R |
| Description | Tumor necrosis factor receptor superfamily member 27 is a protein that in humans is encoded by the EDA2R gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA2R inhibits the proliferation and induces apoptosis of gastric cancer cells by regulating JNK signaling pathway. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human EDA2R Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-EDA2R Detection Antibody: Mouse polyclonal anti-EDA2R |
| Specificity | Validated for detecting natural and recombinant human EDA2R |
| Research Area | Apoptosis |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | EDA2R |
| Full Name | Ectodysplasin A2 Receptor |
| Background | The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. |
| Alternative Names | XEDAR; EDA-A2 Receptor |
| Gene ID | 60401 |
| Uniprot ID | Q9HAV5 |
| GeneCards | EDA2R |
| HGNC | 17756 |
| Ensembl | ENSG00000131080 |
| OMIM | 300276 |
| Involvement in Disease | Diseases associated with EDA2R include Ectodermal Dysplasia 1, Hypohidrotic, X-Linked and Ectodermal Dysplasia. |
| Function | Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. |
| Related Pathways | Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and PEDF Induced Signaling. |
For Research Use Only.
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