Human EDN1 Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-EDN1, IgG2a KappaDetection Antibody: Rabbit purified polyclonal anti-EDN1
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Antigen Detail | |
|---|---|
| Target | EDN1 |
| Description | Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor that in humans is encoded by the EDN1 gene and produced by vascular endothelial cells. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. Endothelin 1 is one of three isoforms of human endothelin. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01886 |
| Isotype | IgG2a, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human EDN1 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-EDN1, IgG2a Kappa Detection Antibody: Rabbit purified polyclonal anti-EDN1 |
| Specificity | Validated for detecting natural and recombinant human EDN1 |
| Research Area | Subcellular Markers |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | EDN1 |
| Full Name | Endothelin 1 |
| Background | This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. |
| Alternative Names | ARCND3; HDLCQ7 |
| Gene ID | 1906 |
| Uniprot ID | P05305 |
| GeneCards | EDN1 |
| HGNC | 3176 |
| Ensembl | ENSG00000078401 |
| OMIM | 131240 |
| Involvement in Disease | Diseases associated with EDN1 include Question Mark Ears, Isolated and Auriculocondylar Syndrome 3. |
| Function | The endothelin family consists of highly potent vasoconstrictive peptides. Three endogenous isoforms are known to exist - ET-1, ET-2 and ET-3. Due to their physiological role as vasoactive peptides, endothelins have been linked to certain cardiac, vascular and renal diseases; endothelin antagonists may therefore play an important role in the treatment of these conditions. Two distinct endothelin receptors have so far been cloned in mammals, classified as ETA and ETB receptors. |
| Related Pathways | Its related pathways are HIF1Alpha Pathway and RET signaling. |
For Research Use Only.
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