Human EFNA1 antibody pair set for ELISA useCapture Antibody: mouse anti-EFNA1 monoclonal antibodyDetection Antibody: rabbit anti-EFNA1 monoclonal antibody conjugated to HRP
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Antigen Detail | |
|---|---|
| Target | EFNA1 |
| Description | EPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A1/EFNA1 and its Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A1 and one of its receptor EphA2 were expressed in xenograft endothelial cells and also tumor cells and play a role in human cancers, at least in part by influencing tumor neovascularization. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01245 |
| Purification | Affinity Chromatography |
| Buffer | Prior to lyophilization: PBS, pH 7.4 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | HRP |
| Clone | RD10336 |
| Purification | Affinity Chromatography |
| Buffer | Prior to lyophilization: PBS, containing 50 % HRP-Protector |
General Product Property | |
|---|---|
| Product Overview | Human EFNA1 antibody pair set for ELISA use Capture Antibody: mouse anti-EFNA1 monoclonal antibody Detection Antibody: rabbit anti-EFNA1 monoclonal antibody conjugated to HRP |
| Specificity | Quantitative determination of Human EFNA1 |
| Range | 39.06-2500 pg/mL |
| Research Area | Nervous system development |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | EFNA1 |
| Full Name | Ephrin A1 |
| Background | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. |
| Alternative Names | EFL1; B61 |
| Gene ID | 1942 |
| Uniprot ID | P20827 |
For Research Use Only.
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